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A chronic endurance exercise was associated with a lower serum MOTS-c concentration compared to the control group, and even more so in high endurance athletes (e.g., cycling, triathlon) than in low/moderate endurance athletes (e.g., football) [16]

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Transition Protocols Moving between cycles requires thoughtful planning: Tapering Down: Week 1 of rest: Reduce dose by 50% Week 2 of rest: Reduce frequency to 2x weekly Weeks 3+: Complete rest Tapering Up: Week 1 of new cycle: Start at 60-70% of target dose Week 2: Increase to 80-90% of target dose Week 3+: Full protocol implementation This gradual approach minimizes disruption and provides smoother transitions between research phases

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