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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

Additionally, individuals whose daily activities are limited by hip osteoarthritis, such as difficulty walking, climbing stairs, or performing routine tasks, may find Durolane helpful

The choice between subcutaneous and intramuscular administration may depend on the formulation, the patients body composition, and the clinics experience

MCL damage can mean 3 to 6 months before return to full activity

Intramuscular injections should be given deep to minimize irritation