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The cytosolic GST enzymes comprise the largest family and based upon amino acid sequences and substrate specificities this family has been divided into seven subclasses identified as alpha (, A), mu (, M), omega (, O), pi (, P), sigma (, S), theta (, T), and zeta (, Z)
However, asparaginase shows little efficacy against solid tumors, which typically have high ASNS levels [441]
doi: 10.1182/blood.V89.10.3503 16 PapayannopoulosVZychlinskyA
Cyclic 3-hydroxymelatonin is not only a metabolite of MEL but also a very effective scavenger of hydroxyl or peroxyl radical [18,26]
J Inherit.Metab Dis 2007;30(3):341-349
