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Several studies have demonstrated the protective glycine and GlyT1 inhibitors effects in experimental ischemia models

Polo D'Enza (RE))

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Nevertheless, our multi-layer integrative approach allowed us to decipher some of the fundamental immunometabolic determinants of CAR T cell response in leukemia patients receiving CD19-CAR T cell therapy

Although several steps in this proposed general mechanism still need detailed confirmation in ex vivo in vitro and in in vivo models through combined metallomic-metabolomic approaches [211,212] and through a systematic physico-chemical study of the involved molecular systems, the collected information allows us to design experimental approaches aimed at verifying the missing steps of the comprehensive model