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This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]

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Glesatinib exhibits antitumor activity in lung cancer models and patients harboring MET exon 14 mutations and overcomes mutation-mediated resistance to type I MET inhibitors in nonclinical models

Hives may occasionally be a symptom of an underlying medical issue, such as an infection or an autoimmune disorder