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This study also showed that combining SFN with DOX allowed for a 50% reduction in DOX dosage while maintaining its anticancer effects

One of the key mechanisms underlying the dark and shrunken morphology of granule cells in the DG during epileptic episodes is excitotoxicity, primarily mediated by excessive glutamate release (Wang and Qin, 2010)

Hence, variants such as rs1695 (Ile105Val) affect enzyme activity and have been linked to cancer risk as well as responses to oxidative stress in conditions like Alzheimer's disease

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Carbamoyl phosphate synthetase II (CSPII) catalyzes this reaction