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Bispecific antibodies for autoimmune and inflammatory diseases: Clinical progress to date

The recombinant construct is transfected into cells for stable or transient expression, then cells are treated with formaldehyde to induce covalent protein:DNA and protein:protein crosslinks, lysed and sonicated to shear the DNA into smaller fragments

When drug-related allergens enter the skin, they react with drug-specific IgEeffector cell complexes and cause the release of histamine and other inflammatory mediators, which results in macroscopic skin symptoms and indicates the possibility of allergy (133)

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