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Oxidative stress is a critical pathophysiological inducer of VPA-induced liver diseases (Ma et al., 2019

the rationality of drug selection based on pharmacokinetic parameters and physicochemical properties of the drug are the important factors to be considered for deciding its suitability of drug for delivery by transdermal route

As many additional mediators derived from PUFAs during infection and inflammation have continued to be identified and characterized, there is now a greater focus on determining which of these lipid mediators enhance specific aspects of host protection and which mediate a return to homeostasis

Studies have shown that the expression level of Sirt3 directly affects the repair ability of mtDNA after IR, and overexpression of Sirt3 increases the radiation resistance of cancer cells, whereas deletion of Sirt3 exacerbates apoptosis, which provides a new target for radiosensitization [249]

doi: 10.1200/JCO.2016.71.1176 13 ChengLZinckeHBluteMLBergstralhEJSchererBBostwickDG