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Guo Y, Pan W, Liu S, Shen Z, Xu Y, Hu L (2020) ERK/MAPK signalling pathway and tumorigenesis (review)

This has been considered the arginine paradox. Several mechanisms have been proposed to explain this phenomenon

Microdosing often means remaining at 0.25 to 1.0 mg long term
Intensive treatment to lower BP has previously been shown to significantly lower the risk of all-cause and cardiovascular death in patients with resistant hypertension versus standard treatment

Can lose effectiveness
