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A Critical Role for Ras-Mediated, Epidermal Growth Factor Receptor-dependent Angiogenesis in Mouse Skin Carcinogenesis

doi: 10.1152/ajpendo.00594.2004 90 DavidsonEPCoppeyLJHolmesAYorekMA

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In addition, the activation of SENP1-Sirt3 signaling leads to the accumulation of glutaminolytic -KG in M2 macrophages, which enhances M2 macrophage polarization through the demethylation of Jmjd3 at H3K27me3, thereby promoting tumor cell growth and survival in the TME (Fig