erythrocyte glutathione reductase activity riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells Effect of dietary riboflavin level
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Science 351 , 12081213 (2016)

Endogenous copper peptides are similarly vital, possibly accelerating the production of elastin and collagen proteins

J Clin Med (2020) 9(8):2575

Nickels et al., 2020

Yes, through 503A pharmacies only, for patients with a documented medical need (allergy to an inactive ingredient, non-commercial strength, or different delivery route), capped at four or fewer prescriptions per month per formulation per pharmacy
