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doi: 10.3389/fphys.2023.1147235 15 ChristianLMGrahamJEPadgettDAGlaserRKiecolt-GlaserJK

For example, ibudilast, a cAMP phosphodiesterase inhibitor, has been shown to reduce pro-inflammatory mediators and enhance neuronal survival in hypertensive rat eyes, emphasizing the importance of targeting neuroinflammation (159)

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The calculated exponent n was found to be 0.55, corresponding to anomalous nonFickian diffusion, whereas the drug release is controlled by diffusion and erosion mechanisms