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A Phase 2b clinical trial (Heffernan 2007, 300 obese patients) tested 1 mg/day subcutaneously over 12 weeks with a weight loss result of ~2.8 kg vs placebo

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The data collected would be fundamentally flawed

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But taking a supplement is only half the battle

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Dietary Adjustments That Reduce GI Side Effects Eat smaller, more frequent meals: Three large meals are far more likely to trigger nausea than five or six smaller ones

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Adequate protein (0.8-1g per pound of body weight) preserves lean mass while the deficit targets fat

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