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This safety profile contrasts sharply with full growth hormone, which carries risks of diabetes development, acromegaly (abnormal tissue growth), increased cancer risk, hypertension, and other systemic effects

Therefore, B12 deficiency should be excluded or treated before starting folic acid in patients with unexplained anaemia or neurological symptoms

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[198] On 31 March 2021, Pfizer and BioNTech announced from initial Phase III trial data that the vaccine is 100% effective for those aged 12 to 15 years of age, with trials for those younger still in progress

10.1007/s10895-021-02852-8 30