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These uremic toxins can have toxic effects on skeletal muscle cells by inhibiting cell proliferation and viability (Figure 2)
However, to neutralize the overproduction of ROS, exogenous antioxidants are required
10.1371/journal.pone.0255252 Summary Keywords bronchopulmonary dysplasia, premature infants, oxidative stress, human milk, antioxidants Citation Yang X, Jiang S, Deng X, Luo Z, Chen A and Yu R (2022) Effects of Antioxidants in Human Milk on Bronchopulmonary Dysplasia Prevention and Treatment: A Review
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A key question arising from these novel studies relates to the potential use of L- or D-thiolesters for key clinical problems associated with opioid analgesics
