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Stage 3: Method-of-Use Patent Expansion (Years 5-20 from NDA) Post-approval clinical research frequently generates new uses for approved drugs, either as single agents in new indications or as components of combination regimens

Once blood return is confirmed, the steel needle is withdrawn, leaving only a small, flexible plastic catheter taped securely in place

Dans une petite tude, des concentrations plasmatiques anormales de glutathion ont t observes chez des patients souffrant de cirrhose, indpendamment de leur alimentation 1

The patients were tested in a special exposure chamber and a nasal clamp was used in order to avoid scent detection, so they breathed through the mouth during the provocations

3B and Supplementary Figs 710)
