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Further, inhibited actions of TNF result in the downregulated production of pro-inflammatory cytokines like IL-1and IL-6, decreased migration of leukocytes and lymphocytes to the inflammatory sites, initiation of apoptotic cascade in TNF-producing cells, including activated T cells and monocytes, enhanced concentration of NF-B inhibitor, and downregulated levels of acute phase proteins and endothelial adhesion molecules [158]

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More recent studies, however, have demonstrated that cancer sensitivity to PHGDH may differ between primary breast tumors and breast cancerderived lung metastases, revealing greater complexity in the exploitation of l-serine metabolism as a metabolic vulnerability (95)

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Gandhi, R