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In adult humans following overnight fast, the normal blood levels of glutamine are 550750 mol/L [21], contributing for more than 20% of the blood amino acid pool [22]

A clinical study showed that it is discrepancy for serum ceruloplasmin (CP) levels in PD patients, and that serum CP reduction is more easily to accelerate the progression of PD than that of serum CP normal patients 36 , which might be the same as the global Cp gene deficiency related parkinsonism symptoms in aceruloplasminemia patients and Cp -/- mice 37,38

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The brain consists of various cell types, including neurons and glial cells (astrocytes, microglia, and oligodendrocytes), each playing a crucial role in maintaining brain function