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First, they engineered different hIPSC lines with patient-derived germline NF1 mutations and with KIAA1549-BRAF fusion, then they differentiated these hIPSCs to multipotent human neural stem cells capable of generating both neuronal and glial lineage cells (hINPCs)

Ketogenesis occurs primarily in the liver, where fatty acids are broken down to produce three main ketone bodies: beta-hydroxybutyrate (BHB), acetoacetate (AcAc), and acetone

Stephen Thomas, MD: I think ID (infectious disease) doctors and epidemiologists (experts in the spread and control of diseases) and anybody who thinks about medicine or science or public health or global health, health security, all these kinds of things

Our findings demonstrated that PA treatment elevated and reduced the number of fragmented and branched mitochondria, respectively, compared to control group

PMID: 28077740