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Description
This leads to decreased calcium levels in the blood (hypocalcemia) by suppressing the secretion of parathyroid hormone and increased renal excretion of calcium (hypercalciuria).

The inability to directly access the brain limits the development of diagnostic measures in psychiatry

Nat Rev Neurosci (2009) 10:78091
Methotrexate and its mechanisms of action
Gastrointestinal Issues : Nausea, abdominal discomfort, and bloating are possible