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Notably, the low dose of 1D228 at 2 mg/kg already achieved same inhibition rate of Tepotinib at 8 mg/kg (TGI, 1D228-2mg/kg/d:74.4%
Loss of the vascular pituitary stalk increases the risk of MPHD 27-fold but required gadolinium-DTPA administration to reliably distinguish presence/absence of vascular stalk (68)
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