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The importance of timing

Diabetes 56: 16381646, 2007

Typically, it is only cats with very serious CKD (for example, IRIS stage four, creatinine level more than 440mmol/L) where optimal management of hyperthyroidism proves difficult, or impossible, without inducing a clinical and laboratory deterioration in renal function

Avoid overcharging and deep discharging to prevent irreversible damage

A dosage this severe is never advisable
