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HL: Conceptualization, Project administration, Supervision, Writing review & editing

2007 Aug Bernard Schmitt, Morgane Vicenzi, Catherine Garrel, Frdric M Denis

108,121 LA exerts biochemical effects in its own right, 122,123 and the bioactivity of eicosanoids is species and context dependent, including both pro-inflammatory and pro-resolving (e.g., lipoxins) actions

The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid

In conclusion, although liver mitochondrial stress may affect various secretory factors such as FGF1 and IL-6, there is no direct evidence yet as to whether they belong to mitokines, and the secretion sources are multi-organized, lacking liver specificity