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Hypothesis: replenish NAD+, slow aging From this comes an attractive therapeutic hypothesis: if we replenish NAD+, we can reverse or slow some aspects of aging

Incapsula incident ID: 461000720056966807-128920942432555534

Ophthalmology 128 , 866876 (2021)

Furthermore, exogenous melatonin administration has been shown to increase the expression of Bcl-2, glutathione peroxidase (GPx), and glutathione S-transferase (GST) in elderly rats, reduce the release of carbon monoxide (CO) and nitric oxide (NO), and lower the levels of cytochrome C, caspases, and lipid peroxidation (LPO), thereby contributing to melatonins anti-aging effects (65, 66)

Treatment of chronic constipation: current pharmacologic approaches and future directions