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Severe reactions to J&J is supposed to be very small (roughly 2-3%)

Tomac et al

There is little reason to not be doing this and I have already given reasons for why you should potentially be taking it even if you are physically castrated
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5) NPT MD (T = 310 K, t = 24 ps, p = 1 bar) with Berendsen thermo- and barostat ( T = 0.1 ps, p = 2.0 ps, separate coupling for solute and solvent) and no restraints
