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Growth factors are universally large proteins that are both metabolically labile and too large to pass the blood- brain barrier (BBB)

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When interpreting our findings, three limitations must be considered

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Finally, for regulatory path, early FDA/EMA engagement on combination-product designation, device dependency (e.g., light/ultrasound), and in vitroin vivo correlation for release is recommended

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Sustained-release dexamfetamine in the treatment of chronic cocaine-dependent patients on heroin-assisted treatment: A randomised, double-blind, placebo-controlled trial

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