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Nrf2 activation inhibits NFB pathway mainly by elevating HO1 expression and antioxidant defenses which neutralize ROS and detoxifying chemicals.118 It also controls NFB pathway through Keap1, which stabilizes the NFB inhibitor (IKB) and represses degradation of NFB kinase inhibitor (IKK), leading negatively to the regulation of NFB pathway.119 NFB exerts its negative effect on Nrf2driven gene expression through p65, along with MafK and histone deacetylase3 (HDAC3)

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