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For example, tumor-associated macrophages can secrete certain metabolites that promote tumor cell resistance to ferroptosis, further influencing tumor progression and the effectiveness of immunotherapy (63)

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Compounding these effects is inflammaging, a state of chronic, low-grade inflammation that develops with age and further disrupts immune regulation

Interestingly, a meta-analysis of tumor gene expression identified that MTHFD2, which is involved in the mitochondrial folate cycle, is overexpressed in multiple cancer types [102]