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Reportedly, serum and urine levels of citrulline, ornithine, threonine, and methionine were found decrease substantially following both single (10 mg/kg, i.p.) and escalating (10, 12.5, 15, 20, and 30 mg/kg, i.p.) administration of MA, returning to baseline levels after a 2-day withdrawal period in Sprague Dawley rats 49

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