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The transport mechanism of CLCs has been well established by structural studies which revealed a homodimeric architecture with each protomer bearing a separate ion transport pathway and three consecutive substrate-binding sites referred to as the external site (S ext ), central site (S cen ) and internal site (S int ) 15,16,17,18,19,20,21,22,23,24,25

The transporter is highly expressed in myocardial cells and consequently attains a high plasma-myocardial gradient of carnitine

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Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Plaque - a deposit of fat, cholesterol, immune cells, fibrin (a clotting protein), and other substances that forms inside arterial walls Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Test tube - a research experiment performed in a test tube, culture dish, or other artificial environment outside of a living organism