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However, superoxide may influence the activities of proteins that contain the [FeS] clusters that mediate the regulation of DNA demethylation in a manner that is regulated by ascorbate

Several research studies have shown that oxidative stress is involved in the misfolding and accumulation of mutant huntingtin protein, which induces proteotoxicity and impairs oxidative metabolism, leading to neuronal damage and death 39 , 40

Stress, both physiological and biological, is the organisms response to stressors, including environmental conditions
Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage

Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators