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SIRT1 influences critical hepatic processes by deacetylating key transcription factors and enzymes involved in glucose and lipid metabolism, inflammation, DNA repair, mitochondrial function, cell proliferation, and cellular senescence (Wu et al., 2022

Conversely, treatment of A375 cells with 4A and 5A did not alter the cellular ROS concentration

This demonstrates its potential as a new strategy for tumor immunotherapy 176

205207 GSDMD is the substrate of caspase-1, which will be cleaved to separate GSDMD-N from GSDMD-C