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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

The applicant noted that it is concurrently seeking FDA authorization for in vitro diagnostic (IVD) use in the clinical microbiology laboratory for automated quantitative AST by minimal inhibitory concentration (MIC) of isolated colonies ( for aerobic and facultative anaerobic gram-negative Enterobacterales and non-Enterobacterales

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Skeen TM, et al