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Recruitment occurred through the Michael J

These studies mostly involved bioactivity-guided strategies which, due to methodological limitations, restricted the available range of examinable taxa to the few larger representatives (Herzig et al., 2019

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NADPH-dependent disulfide reductases Although there are hundreds of different NADPH-dependent enzymes in biology, each of which has the ability to use electrons extracted from NADPH to reduce specific organic or inorganic substrates, only two small groups of these enzymes, the Trx-disulfide reductases (TrxRs) and the glutathione-disulfide (GSSG)-reductases (Gsrs), can reduce an intracellular disulfide [42]