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Moreover, there is increasing evidence that ferroptosis is an autophagy-dependent form of cell death and that either intracellular transition activation or abnormally elevated lysosomal activity can cause the accumulation of intracellular iron ions and lipid peroxides, which in turn promotes ferroptosis

mRNA expression of Gsta4 was highest in the stomach, while lower levels of Gsta4 mRNA were observed in the liver and kidney

In this article, we provide an overview of the potential effects of Chinese Yang/Qi-invigorating tonic botanical drugs on ameliorating CKD and its complications, with particular emphasis on the possible mechanism(s) involving mitochondria-associated signaling pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 538.Zhang, Y

In addition, after ex vivo stimulation with phorbol myristate acetate (PMA)/ionomycin, IFN-, granzyme B (GzB), and perforin expression were increased post-dose in several participants, with significant changes being detected in CD8 + T cells for GzB and perforin ( n = 5, Fig