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Since activation of the inflammasome further promotes the release of IL-1, it could be part of an inflammatory positive-feedback loop that prevents polarisation of macrophages towards an anti-inflammatory phenotype 8

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When mice were orally administered 50 mg/kg of this compound, MNAM production decreased by approximately 80% within 2 h

1 NOTE : Different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but sublingual is considered a pharmaceutical term by the FDA, so dietary supplements are not allowed to 'label' using that word