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Rheum officinale enema can also reduce TMAO and TMA levels in the serum of 5/6Nx CKD rats by decreasing certain TMAO-related bacteria, inhibit the expression of inflammatory markers (interleukin-6, tumour necrosis factor-, and interferon-), alleviate renal interstitial fibrosis, and slow the progression of CKD (Ji et al., 2021)

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One of its key mechanisms is promoting the production of alpha brain wavesbrain waves associated with a relaxed yet alert state [9]

The pharmacokinetics may differ slightly

30 Whereas IENF density and mtDNA copies/cell did not change after therapy, improvements in neuropathic pain, paresthesias, and symptoms of numbness were observed