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The treatment of leukemic cells with curcumin increased intracellular ROS levels, and an additional treatment with the strong antioxidant, glutathione (GSH), and the overexpression of curcumin-binding enzymes partially reversed the effects of curcumin
Before the origin of genes and proteins, simple molecular systems such as monomeric Cys-FeS clusters could have driven protometabolism
88,89 mTOR also has been manifested to control the translation of MK-2 kinase, which phosphorylates the specific RNA-binding protein ZFP36L1, preventing the degradation of the transcripts of many SASP factors
Nutrients 11 , 295 (2019)
