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Otani, J

In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

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Studies have shown that transferring microbiota from adult male mice to immature females results in shifts in hormone levels (notably elevated testosterone), as well as changes in the metabolome and autoantibody production