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Abbreviations ALS: Amyotrophic lateral sclerosis CCS: Copper chaperone for SOD1 CSF: Cerebrospinal fluid ISF: Interstitial fluid non- SOD1 ALS: Amyotrophic lateral sclerosis without mutations in the SOD1 gene PD: Parkinsons disease PSP: Progressive supranuclear palsy SOD1: Cu/Zn-superoxide dismutase SOD1 -ALS: Amyotrophic lateral sclerosis with mutations in the SOD1 gene References Andersen PM, Al-Chalabi A

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