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This is likely to be because all loci of SMA types I to III are mapped to the same locus, chromosome 5q13

Optimization of enzyme-linked immunosorbent assay kit protocol to detect trimethylamine N-oxide levels in humans

Oxidative stress can result in vascular endothelial cell injury (83, 230234), neuronal cell compromise (66, 122, 123, 152, 156, 162, 233, 235245), alterations in neurotransmitters (69, 246, 247), myelin degradation (79, 224, 248252), cell senescence (55, 112, 253255), loss of stem cell proliferation (66, 168, 228, 241, 251, 256259), and cognitive impairment (120, 121, 200, 223, 243, 245, 260266)

The heterogeneity in this study was substantial, and we speculate that most of the heterogeneity may have come from clinical sources

Chromatographic separation was carried out on an Acquity UPLC BEH Amide column (1 150 mm, 1.7 m