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Secondly, motivated by the need for a more relevant measure of destructive brain pathology, AVONEX clinical trial investigators pre-specified brain atrophy as an exploratory measure, and applied a new highly precise measure of brain atrophy, the so-called brain parenchymal fraction, to images collected during the trial
These results supported the hypothesis that ACTL6A impacts GSH de novo synthesis mainly by regulating GCLC expression
Integrated platforms (e.g., brain organoids coupled with clinical cohorts) are needed to define therapeutic windows and contraindications
