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It adversely affects skeletal muscles, including the respiratory muscles, leading to decreased diaphragmatic mass and diaphragmatic strength that results in respiratory failure

Front Med (Lausanne) 2021;8:724224

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Barbara Crannell, RN, PMP joined Lifemed Institute in 2017

Overall, the resolvable range of the Ycf1 R-domain coincides with the region containing the highest sequence conservation to CFTR, which possesses a longer R-domain than Ycf1 but otherwise conserved kinase motifs (Fig