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Pasternak et al
Excessive alcohol use activates cytochrome P450 2E1 (CYP2E1), producing harmful reactive oxygen species (ROS) and reducing glutathione, a vital antioxidant
The GSTP1 gene codes for the enzyme glutathione S -transferase-pi and is located on chromosome 11q13
This effect may have occurred by the decrease of content of cardiolipin in the mitochondrial membrane, in which synthesis is stimulated by thyroid hormones
American journal of physiology Lung cellular and molecular physiology
