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It plays a beneficial role in protecting kidney diseases such as AKI and DN

10.1016/j.celrep.2020.02.049 49 FengH.StockwellB
This FDA-cleared, non-invasive procedure works by stimulating the skins natural collagen production, which helps to give the skin a lifted and rejuvenated appearance

ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo
This would suggest that 3D cultures may be used to study MB behavior and drug sensitivity, mimicking better the in vivo physical conditions (113)