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52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

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PLoS One 10 (4), e0123454

The copper binding occurs through a specific square-planar pyramid configuration involving nitrogen atoms from histidine and glycine, plus a deprotonated amide nitrogen and carboxyl oxygen from lysine