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CrossSectional Comparison of Therapies Therapeutic strategies for PD can be broadly categorized into mainstream and emerging approaches, each differing in mechanisms, efficacy, and limitations (see Table 2)

Many of the DRL-sorted studies falling within the Valley of Death DRLs 46 separating typical university design research at DRLs 13 from typical industry and government design research at DRLs 79 are greatly facilitated by AI-enhanced computational platforms, including agent-based co-simulation platforms

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Another study aimed to downregulate the expression of immune checkpoint molecules on T cells using the SIINFEKL peptide vaccine (Jeon et al., 2024)