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Mutations in the HADH gene have been reported in a rare disorder known as familial hyperinsulinemic hypoglycemia that is characterized by abnormally high levels of insulin and unusually low levels of blood sugar

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Complementing this, cell-based therapies, particularly the transplantation of stem cell-derived retinal pigment epithelium (RPE), aim to address the underlying cellular dysfunction in diseases like AMD, offering the potential to stabilize and perhaps restore retinal structure (Sakai et al., 2025)

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