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doi: 10.1186/s13046-023-02629-w 184 LangXGreenMDWangWYuJChoiJEJiangLet al

Lee et al [99], demonstrated that ascorbic acid induces decomposition of lipid hydroperoxide (13-( S )-hydroperoxy-( Z,E )-9,11-octadecadienoic acid;(13-HPODE) in presence of transition metals to DNA-reactive bifunctional electro-philes namely 4-oxo-2-nonenal, 4,5-epoxy-2(E)-decenal and 4-hydroxy-2-nonenal

While no small-molecule inhibitors of SEDS proteins have been discovered to date, the transpeptidase activity of the PBPs is inhibited by the well-known class of antibiotics called the -lactams