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Furthermore, clinical manifestations of withdrawal, such as dysphoria and irritability, mirror neurobiological adaptive mechanisms that involve greater stress sensitivity and hyperactivation of the hypothalamic-pituitary-adrenal axis, which could account for the increase in BDNF levels [38, 39]

It has also been isolated from placenta, ovaries, testes, adrenal glands, thymus, retina, and pancreas tissues

Am J Physiol Regul Integr Comp Physiol 304: R810R817, 2013

Cohen 2010)

Nguyen D-D
